2. Signaling Pathways
  3. GPCR/G Protein
  4. Leukotriene Receptor

Leukotriene Receptor

Leukotriene Receptor

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Leukotriene Receptor (cys-LTs) are a family of potent bioactive lipids that act through two structurally divergent G protein-coupled receptors, termed the CysLT1 and CysLT2 receptors. The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Leukotriene Receptor is a member of the superfamily of G protein-coupled receptors and uses a phosphatidylinositol-calcium second messenger system. Activation of CysLT1 by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung. Leukotriene receptor antagonists, called LTRAs for short, are a class of oral medication that is non-steroidal. They may also be referred to as anti-inflammatory bronchoconstriction preventors. LTRAs work by blocking a chemical reaction that can lead to inflammation in the airways.

Leukotriene Receptor Isoform Specific Products:

Leukotriene Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-119055
    Sch 33303
    		Inhibitor
    Sch 33303 is an orally active antiallergy agent that inhibits the release of the sulfidopeptide leukotrienes. Sch 33303 is promising for research of asthma.
    Sch 33303
  • HY-168484
    T-10430
    		Agonist
    T-10430 is a potent and orally active leukotriene B4 receptor 2 (BLT2) agonist. T-10430 has the potential for the research of psoriasis.
    T-10430
  • HY-W747565
    Leukotriene B4-3-aminopropylamide
    Leukotriene B4-3-aminopropylamide (LTB4-APA) is a leukotriene immunomodulator.
    Leukotriene B4-3-aminopropylamide
  • HY-19042
    YM-16638
    		Antagonist
    YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep.
    YM-16638
  • HY-136831
    SR2640
    		Antagonist
    SR2640 is a highly efficient and selective LTD4/LTE4 antagonist that can specifically inhibit the smooth muscle contractions induced by LTD4 in the guinea pig ileum and trachea in a concentration-dependent manner, without affecting the contractions caused by histamine. SR2640 can concentration-dependently prevent the binding of 0.4 nM [3H] LTD4 to membrane receptors in guinea pig lung tissue, with an IC50 of 23 nM. SR2640 can shift the dose-response curve for bronchoconstriction induced by intravenous LTD4 in guinea pigs to the right, and the extent of this shift is positively correlated with the dose of SR2640 administered. SR2640 can be used in asthma research.
    SR2640
  • HY-115390
    14,15-Dehydro Leukotriene B4
    		Antagonist
    14,15-Dehydro Leukotriene B4 (Compound 4) is a LTB4 receptor antagonist. 14,15-Dehydro Leukotriene B4 also has a higher binding affinity for BLT1 with a Ki value of 27 nM and BLT2 with a Ki value of 473 nM. 14,15-Dehydro Leukotriene B4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 µM.
    14,15-Dehydro Leukotriene B4
  • HY-107611
    Ro 24-5913
    		Antagonist
    Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.
    Ro 24-5913
  • HY-17492S1
    Zafirlukast-13C,d3
    		Antagonist
    Zafirlukast-13C,d3 is the 13C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.
    Zafirlukast-<sup>13</sup>C,d<sub>3</sub>
  • HY-117943
    (rac)-ONO-2050297
    		Antagonist
    (rac)-ONO-2050297 is a benzoxazole derivative and a potent biCysLT1/CysLT2 antagonist with IC50 values are 17 nM and 0.87 nM respectively.
    (rac)-ONO-2050297
  • HY-137350
    12-epi-LTB4
    		Agonist
    12-epi-LTB4 is an agonist for BLT1 and BLT2. 12-epi LTB4 exhibits a partial agonistic activity against mBLT1 and mBLT2, and induces phosphorylation of extracellular signal-regulated kinase in primary mouse keratinocytes.
    12-epi-LTB4
  • HY-131651
    Leukotriene B4 ethanolamide
    		Antagonist
    Leukotriene B4 ethanolamide (LTB4 ethanolamide) is an antagonist and a partial agonist for Leukotriene B4 (LTB4) receptor 1 (BLTR1). Leukotriene B4 ethanolamide ameliorates the tumor progression, which is only asscociated with inflammation.
    Leukotriene B4 ethanolamide
  • HY-N8892
    Triptinin B
    		Antagonist
    Triptinin B (compound 2) is a LTD4 antagonist that can be isolated from Tripterygium wilfordii.
    Triptinin B
  • HY-124099
    SCH 40120
    SCH 40120 is a potent leukotriene inhibitor with antiinflammatory effects. SCH 40120 suppresses T cell proliferative responses, antigen-specific and poly-clonally-induced in vitro antibody responses. SCH 40120 suppresses an edematous response and inhibits the recruitment of circulating neutrophils into sites of inflammation. SCH 40120 is proming for rasearch of anti-psoriatic agents.
    SCH 40120
  • HY-156960A
    JNJ-40929837 succinate
    		Inhibitor
    JNJ-40929837 succinate is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research.
    JNJ-40929837 succinate
  • HY-W744842
    γ-Linolenic acid ethyl ester-d5
    γ-Linolenic acid ethyl ester-d5 (Ethyl γ-linolenate-d5) is the deuterium labeled γ-Linolenic acid ethyl ester (HY-108396). γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B4 receptor 4 (LTB4) antagonist.
    γ-Linolenic acid ethyl ester-d<sub>5</sub>
  • HY-107609
    BAY-u 9773
    		Antagonist
    BAY-u 9773 is a non-selective antagonist of the CysLT receptors (cysteinyl leukotrienes receptors) with about the same IC50 for CysLT1 and CysLT2. BAY-u9773 is used for the inhibition of LT responses.
    BAY-u 9773
  • HY-105176A
    (R)-Ontazolast
    		Inhibitor
    (R)-Ontazolast ((R)-BIRM-270) is a potent inhibitor of leukotriene biosynthesis, effectively blocking the release of arachidonic acid and demonstrating an impressive IC50 value of 0.001 microM in human polymorphonuclear leukocytes.
    (R)-Ontazolast
  • HY-107608R
    Leukotriene B4 (Standard)
    Leukotriene B4 (Standard) is the analytical standard of Leukotriene B4. This product is intended for research and analytical applications. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4 (Standard)
  • HY-106929B
    Moxilubant hydrochloride
    		Antagonist
    Moxilubant hydrochloride (CGS-25019C hydrochloride) is an orally active BLT1 antagonist which inhibits LTB4 signaling with a potency of 2-4 nM. Moxilubant hydrochloride can be used for cancer research.
    Moxilubant hydrochloride
  • HY-101944
    Iralukast
    Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.
    Iralukast
Cat. No. Product Name / Synonyms Application Reactivity
Leukotriene Receptor Isoform Comparison

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